Thousands of circulating proteins have been shown to be hallmarks of emerging disease, response to treatment, or a patients’ prognosis. The identification of these small molecule biomarkers holds a great promise for significant improvement of personalized medicine based on simple blood tests. For instance, diagnosis and prognosis with biomarkers (e.g. carcinoembryonic antigen (CEA)) has significantly improved patient survival and decreased healthcare costs in colorectal cancer patients. Unfortunately, despite significant investments to increase the number of biomarker studies, only ~150 out of thousands of identified biomarkers have currently been implemented in clinical practice. This is mainly caused by the time-consuming process of reliably detecting biomarkers, the irreproducibility of studies that determine a biomarkers’ clinical value, and by a mismatch in studies that are performed by academia and what is required for regulatory and market approval.
Project funding:
COST actions
Project results:
To increase the number of clinically validated biomarkers, rather than further increasing the number of biomarker discovery studies, CliniMARK improve the quality and reproducibility of studies and establish a coherent biomarker development pipeline from discovery to market introduction.
Period of project implementation: 2017-03-14 - 2021-03-13
Project partners: Croatia, Cyprus, Czech Republic, Greece, Iceland, Ireland, Israel, Malta, Netherlands, Norway, Poland, Portugal, Romania, Serbia, Switzerland, Austria, Bosnia and Herzegovina, Denmark, Estonia, France, Germany, Slovakia, Spain, United Kingdom
